Description

1,4:3,6-Dianhydromannitol CAS NO 28218-68-0 is a specialized bicyclic diol derivative of mannitol, serving as a versatile chiral building block and intermediate in advanced organic synthesis. Its rigid, V-shaped structure is critical for imparting specific stereochemical and conformational properties to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries who require high-purity, enantiomerically defined intermediates for developing active pharmaceutical ingredients (APIs), ligands, and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of nucleoside analogs, antiviral drugs, and other bioactive molecules.
• Chiral Ligand & Catalyst Synthesis: Used to construct sophisticated ligands for asymmetric catalysis and molecular recognition.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for producing specialty polyesters and polycarbonates with unique thermal and mechanical properties.
• Material Science: Employed in the development of liquid crystals, dendrimers, and other advanced functional materials.
• Chemical Research: Serves as a standard and starting material in methodological development and stereochemical studies.

Basic Information

Item	Detail
Product Name	1,4:3,6-Dianhydromannitol
CAS No.	28218-68-0
Molecular Formula	C6H10O4
Molecular Weight	146.14 g/mol
Synonyms	Isomannide; 1,4:3,6-Dianhydro-D-mannitol; Dianhydromannitol; D-Isomannide; (3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol; Furo[3,2-b]furan-3,6-diol, hexahydro-, (3R,3aR,6S,6aR)-; Dianhydro-D-mannitol
EINECS	Contact for details

Quality Control

Our 1,4:3,6-Dianhydromannitol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.