Description

12-Deoxyphorbol 13-Angelate is a bioactive diterpene ester belonging to the phorbol family, a class of compounds known for their potent biological activity. This specific derivative is of significant interest for advanced research in pharmacology and chemical biology due to its unique structural framework. It serves as a critical reference standard and a key synthetic intermediate for researchers and developers in the pharmaceutical, biotechnology, and agrochemical sectors.

Application

• Pharmacological Research: Used as a reference standard and a key intermediate in the study of protein kinase C (PKC) modulation and related signal transduction pathways.
• Chemical Synthesis: Serves as a sophisticated building block for the synthesis of novel diterpene derivatives with potential therapeutic applications.
• Biochemical Assays: Employed in high-throughput screening and in-vitro assays to investigate cellular mechanisms and identify new drug targets.
• Academic Research: A vital tool for universities and research institutions exploring natural product chemistry, medicinal chemistry, and molecular pharmacology.
• Agrochemical Development: Investigated for its potential as a lead compound in the development of new plant growth regulators or bioactive agents.

Basic Information

Product Name	12-Deoxyphorbol 13-Angelate
CAS No.	28152-96-7
Molecular Formula	C27H36O6
Molecular Weight	456.58 g/mol
Synonyms	12-Deoxyphorbol 13-angelate; 12-Deoxyphorbol angelate; 12-DPA; 13-Angeloyl-12-deoxyphorbol; 12-Deoxyphorbol 13-(2-methylbut-2-enoate); Phorbol 13-angelate, 12-deoxy-; (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Hydroxymethyl)-5,5-dimethyl-3-(1-methyl-2-oxo-2-((E)-3-methylbut-2-en-1-yl)oxy)ethyl)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benz[1,2-e]azulene-9,9b(2H)-diol
EINECS	Contact for details

Quality Control

Our 12-Deoxyphorbol 13-Angelate is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.