Description

4-[4-(Trifluoromethoxy)Phenoxy]Piperidine is a high-value, multi-functional piperidine derivative and a key advanced pharmaceutical intermediate (API) in modern organic synthesis. Its molecular structure, featuring a trifluoromethoxy phenoxy group, makes it a critical building block for developing novel bioactive compounds with enhanced metabolic stability and membrane permeability. This compound is essential for research and production in pharmaceutical chemistry, agrochemicals, and material science, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethoxy group can improve biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor or core structure for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Investigated as a monomer or additive for developing specialty polymers with unique thermal or optical properties.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme function and receptor interactions in biological systems.

Basic Information

Product Name	4-[4-(Trifluoromethoxy)Phenoxy]Piperidine
CAS No.	28033-37-6
Molecular Formula	C12H14F3NO2
Molecular Weight	261.24 g/mol
Synonyms	4-[4-(Trifluoromethoxy)phenoxy]piperidine; 1-[4-(Trifluoromethoxy)phenoxy]-4-piperidine; 4-(4-Trifluoromethoxyphenoxy)piperidine; Piperidine, 4-[4-(trifluoromethoxy)phenoxy]-; 28033-37-6; 4-(α,α,α-Trifluoro-p-tolyloxy)piperidine
EINECS	Contact for details

Quality Control

Our 4-[4-(Trifluoromethoxy)Phenoxy]Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.