Description

Nicergoline is a semi-synthetic ergot alkaloid derivative known for its vasoactive and neuroprotective properties. This compound is a critical active pharmaceutical ingredient (API) used in the formulation of medications targeting cerebral and peripheral circulatory disorders. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for cognitive impairment, vertigo, and age-related vascular conditions. Our supply of Nicergoline CAS NO 27848-84-6 ensures high purity and reliable consistency for demanding production and research applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for cerebrovascular insufficiency and cognitive disorders.
• Vasodilator Formulations: Used in drugs aimed at improving peripheral and cerebral blood circulation.
• Neuroprotective Research: Serves as a key compound in preclinical and clinical research studying neuroprotection and cognitive enhancement.
• Metabolic Agent: Incorporated into formulations designed to enhance neuronal metabolism and oxygen utilization.
• Anti-vertigo Medications: A core component in treatments for symptoms of vertigo and tinnitus of vascular origin.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for drug testing and verification.

Basic Information

Product Name	Nicergoline
CAS No.	27848-84-6
Molecular Formula	C24H26BrN3O3
Molecular Weight	484.39 g/mol
Synonyms	10-Methoxy-1,6-dimethylergoline-8β-methanol 5-bromonicotinate ester; 1-Methyl-10α-methoxy-9,10-dihydrolysergol 5-bromonicotinate; Sermion; Nicotergoline; Nargoline; Eticer; Varson; Nimergoline
EINECS	248-680-6

Quality Control

Our Nicergoline is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards suitable for pharmaceutical applications, with comprehensive analysis including identity, assay, and impurity profiling. Certificates of Analysis (COA) are provided with every shipment, detailing compliance with in-house specifications. We support audits and can provide documentation relevant to cGMP and ICH Q7 guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Solvent Residues (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.