Description

(1R,8As)-1,2,6,7,8,8A-Hexahydro-1,8A-Dimethyl-7-Isopropylidenenaphthalene CAS NO 27840-40-0 is a high-purity, specialized sesquiterpene hydrocarbon with a unique fused ring structure. This compound serves as a critical advanced intermediate and building block in the synthesis of complex organic molecules, valued for its defined stereochemistry and reactive isopropylidene moiety. It is essential for R&D and production in the pharmaceutical, aroma chemical, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in steroid and terpenoid-based drug discovery.
• Fragrance & Flavor Synthesis: Serves as a precursor for high-value aroma chemicals, contributing woody, amber, or musky olfactory notes in premium perfumery.
• Organic Synthesis & Catalysis: Used as a starting material or ligand precursor in asymmetric synthesis and catalytic reactions due to its rigid, three-dimensional framework.
• Material Science Research: Investigated as a monomer or additive for specialty polymers and advanced materials requiring specific thermal or optical properties.
• Agrochemical Development: Intermediate in the research and production of next-generation pesticides and plant growth regulators.
• Reference Standard: Provides a high-purity analytical standard for quality control and research in chemical analysis laboratories.

Basic Information

Product Name	(1R,8As)-1,2,6,7,8,8A-Hexahydro-1,8A-Dimethyl-7-Isopropylidenenaphthalene
CAS No.	27840-40-0
Molecular Formula	C15H22
Molecular Weight	202.34 g/mol
Synonyms	7-Isopropylidene-1,8a-dimethyl-1,2,6,7,8,8a-hexahydronaphthalene; (1R,8aS)-1,2,6,7,8,8a-Hexahydro-1,8a-dimethyl-7-(1-methylethylidene)-Naphthalene; 7-Isopropylidene-1,8a-dimethyl-1,2,3,4,6,7,8,8a-octahydronaphthalene (related isomer); Cadina-4,9-diene (related skeleton); Sesquiterpene hydrocarbon C15H22; 1,8a-Dimethyl-7-isopropylidene-1,2,6,7,8,8a-hexahydronaphthalene
EINECS	Contact for details

Quality Control

Our (1R,8As)-1,2,6,7,8,8A-Hexahydro-1,8A-Dimethyl-7-Isopropylidenenaphthalene is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity assessment by GC or HPLC, to ensure it meets the precise requirements of advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to support regulatory filings (e.g., FDA DMF, CEP).

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, containers should be kept sealed and purged after each use to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Assay (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral GC/HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.