Description

4Alpha-Phorbol 12,13-Didecanoate is a specific, high-purity phorbol ester derivative, a class of compounds known for their potent biological activity. This compound is a critical research-grade biochemical tool used primarily in pharmacological and biological studies to investigate protein kinase C (PKC) signaling pathways. It is essential for researchers and scientists in the pharmaceutical, biotechnology, and academic sectors who require reliable, well-characterized compounds for mechanistic studies, assay development, and as a reference standard.

Application

• Biochemical Research: As a potent activator of Protein Kinase C (PKC) isoforms, used to study signal transduction, cell proliferation, and tumor promotion mechanisms.
• Pharmacological Studies: Employed as a reference standard and tool compound in drug discovery programs targeting PKC-related diseases, including cancer and inflammatory disorders.
• Cell Biology: Used to induce specific cellular responses in vitro, facilitating research into apoptosis, differentiation, and gene expression.
• Toxicology & Safety Assessment: Serves as a model compound in studies investigating the biological effects of phorbol esters and tumor promoters.
• Academic Research: A key reagent in university and institutional labs for fundamental research in molecular biology and biochemistry.
• Diagnostic Development: Potential use in the development and calibration of assays designed to measure PKC activity or screen for PKC modulators.

Basic Information

Product Name	4Alpha-Phorbol 12,13-Didecanoate
CAS No.	27536-56-7
Molecular Formula	C40H64O8
Molecular Weight	672.9 g/mol
Synonyms	4α-Phorbol 12,13-Didecanoate; Phorbol 12,13-Didecanoate; 4α-PDD; 4-α-Phorbol Didecanoate; NSC 153858; 1,1a,1b,4,4a,7a,7b,8,9,9a-Decahydro-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one didecanoate
EINECS	Contact for details

Quality Control

Our 4Alpha-Phorbol 12,13-Didecanoate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0 %
Solubility	Soluble in DMSO, ethanol, acetone; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.