Description

Poly(Oxy-1,2-Ethanediyl), .Alpha.-Acetyl-.Omega.-(Acetyloxy)- is a specialized acetyl-capped poly(ethylene glycol) derivative, a key building block in advanced polymer synthesis and surface modification. This compound is valued for its dual reactive termini, enabling precise functionalization and controlled chain extension in demanding applications. It is essential for R&D and production in the pharmaceutical, biomedical, and specialty chemical industries, where consistent quality and reliable supply are critical.

Application

• Pharmaceutical Intermediates: Serves as a crucial precursor for synthesizing PEGylated drug conjugates, improving solubility and bioavailability of active pharmaceutical ingredients (APIs).
• Bioconjugation & Linker Chemistry: Used to create heterobifunctional cross-linkers for attaching biomolecules (e.g., proteins, peptides) to surfaces, nanoparticles, or other polymers.
• Polymer Modification: Acts as a macro-initiator or terminating agent in controlled polymerization techniques (e.g., ring-opening polymerization) to create block copolymers with tailored properties.
• Surface Engineering: Employed to modify material surfaces (e.g., glass, metals, plastics) to introduce hydrophilic PEG layers, reducing protein adsorption and fouling.
• Hydrogel Formation: A key component in the synthesis of cross-linked, water-swellable hydrogels for biomedical applications like tissue engineering and drug delivery matrices.
• Specialty Surfactants & Dispersants: Utilized in formulating high-performance surfactants and stabilizers for coatings, inks, and advanced material dispersions.

Basic Information

Product Name	Poly(Oxy-1,2-Ethanediyl), .Alpha.-Acetyl-.Omega.-(Acetyloxy)-
CAS No.	27252-83-1
Molecular Formula	CnH2n+2On+2 (n varies by PEG chain length) / Typically represented as CH3CO-(OCH2CH2)n-OCOCH3
Molecular Weight	Varies by 'n' (PEG chain length). Contact for details on specific molecular weight grades.
Synonyms	α-Acetyl-ω-(acetyloxy)poly(oxy-1,2-ethanediyl); Polyethylene glycol diacetate; PEG diacetate; Acetylated PEG; Acetyl-PEG-acetate; HO-PEG-OAc, acetylated; Bis(acetoxy) poly(ethylene glycol); Poly(ethylene oxide) diacetate
EINECS	Contact for details

Quality Control

Our Poly(Oxy-1,2-Ethanediyl), .Alpha.-Acetyl-.Omega.-(Acetyloxy)- is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure consistent purity, molecular weight distribution, and functional group integrity. Certificates of Analysis (COA) detailing key parameters such as assay, degree of acetylation, and residual solvent levels are available upon request. We support compliance with relevant guidelines for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid (varies by MW)
Identification (IR)	Conforms to structure
Assay (NMR/Titration)	≥ 95.0%
Average Molecular Weight (GPC)	As per ordered grade (e.g., 400, 600, 1000, 2000 Da)
Polydispersity Index (PDI)	≤ 1.10
Water Content (KF)	≤ 0.5%
Residual Solvent (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.