Description

Succinyl Phosphonate CAS NO 26647-82-5 is a specialized organophosphorus compound that functions as a potent and selective inhibitor of the enzyme succinyl-CoA synthetase (SCS). This compound matters for researchers and developers as it provides a critical tool for probing metabolic pathways, specifically the citric acid (Krebs) cycle, enabling the study of energy metabolism and related diseases. It is primarily needed by biochemical research laboratories, pharmaceutical R&D teams, and academic institutions focused on enzymology, metabolic disorders, and anticancer drug discovery.

Application

• Enzymology Research: Used as a specific active-site inhibitor to study the structure, function, and kinetics of succinyl-CoA synthetase (SCS).
• Metabolic Pathway Analysis: A key tool for investigating perturbations in the citric acid cycle and mitochondrial energy production in cell-based and in vitro assays.
• Pharmaceutical R&D: Serves as a lead compound or biochemical probe in the development of therapeutic agents targeting metabolic diseases and certain cancers.
• Biochemical Assay Development: Employed as a standard or control in high-throughput screening (HTS) platforms to identify novel SCS modulators.
• Academic Research: Facilitates fundamental studies in cellular metabolism, bioenergetics, and the role of SCS in bacterial and eukaryotic systems.

Basic Information

Product Name	Succinyl Phosphonate
CAS No.	26647-82-5
Molecular Formula	C4H7O6P
Molecular Weight	182.07 g/mol
Synonyms	Succinylphosphonate; (3-Carboxypropyl)phosphonic acid; Suc-P; Succinyl CoA Synthetase Inhibitor; SCS Inhibitor; 4-Phosphonobutanoic Acid; NSC 163880; Succinylphosphonic Acid
EINECS	Contact for details

Quality Control

Our Succinyl Phosphonate is manufactured under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.