Description

Petasin is a natural sesquiterpene compound primarily isolated from the butterbur plant (*Petasites hybridus*). This bioactive molecule is valued for its significant role as a reference standard in analytical research and for its potential in pharmacological studies. It serves as a critical component for researchers and manufacturers in the pharmaceutical, nutraceutical, and analytical chemistry sectors who require high-purity, well-characterized compounds for method development, quality control, and biological activity screening.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of butterbur extracts and related pharmaceutical formulations.
• Analytical Research: Serves as a critical standard in High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), and other chromatographic methods for quantitative analysis.
• Bioactivity Studies: Employed in preclinical research to investigate its potential pharmacological properties, including anti-inflammatory and spasmolytic effects.
• Nutraceutical Quality Control: Essential for standardizing and authenticating butterbur-based dietary supplements, ensuring product potency and safety for consumers.
• Chemical Synthesis Intermediate: Acts as a starting material or intermediate for the semi-synthesis of novel derivatives with enhanced biological activity.
• Academic & Institutional Research: Used in universities and research institutes for studies in natural product chemistry, phytochemistry, and pharmacognosy.

Basic Information

Product Name	Petasin
CAS No.	26577-85-5
Molecular Formula	C20H32O3
Molecular Weight	320.47 g/mol
Synonyms	Petasin; (-)-Petasin; (3S,3aR,4S,9aR)-4-(Acetyloxy)-3-(2-methylpropyl)-3a,4,5,8,9,9a-hexahydro-3H-benzo[f]isobenzofuran-1-one; NSC 267240; Petasitenine; Petasitin; S-Petasin
EINECS	Contact for details

Quality Control

Our Petasin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets stringent specifications for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.