Description

Aescin Ib(Sh) is a purified, high-purity saponin compound derived from the horse chestnut tree (*Aesculus hippocastanum*). This specific isomer is valued for its potent venotonic and anti-inflammatory properties, making it a critical active pharmaceutical ingredient (API) and a key reference standard for research and quality control. It is essential for manufacturers and researchers in the pharmaceutical, nutraceutical, and cosmeceutical industries seeking to develop or validate products for vascular health and inflammation management.

Application

• Pharmaceutical Active Ingredient (API): Primary component in prescription and OTC medications for chronic venous insufficiency (CVI), hemorrhoids, and post-operative edema.
• Reference Standard: Used in analytical laboratories for the identification, assay, and purity testing of aescin-containing raw materials and finished products via HPLC, TLC, or MS.
• Nutraceutical Formulations: Incorporated into dietary supplements and herbal extracts targeting circulatory support and anti-inflammatory benefits.
• Cosmeceutical Products: Key ingredient in topical creams, gels, and serums designed to reduce under-eye circles, puffiness, and the appearance of varicose veins.
• Biomedical Research: Utilized in preclinical studies to investigate mechanisms of vascular permeability, inflammation, and endothelial cell function.
• Veterinary Medicine: Applied in formulations for treating swelling and inflammation in animals.

Basic Information

Product Name	Aescin Ib(Sh)
CAS No.	26339-90-2
Molecular Formula	C55H86O24
Molecular Weight	1131.26 g/mol
Synonyms	Aescin Ib; Aescin I b; Escin Ib; β-Escin; Escin IIb; Aesculus saponin I; Horse Chestnut Saponin I; (3β,16α,21β,22α)-21,22-Bis[[(2E)-2-methyl-1-oxo-2-butenyl]oxy]-16,28-dihydroxyolean-12-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranosiduronic acid
EINECS	Contact for details

Quality Control

Our Aescin Ib(Sh) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets stringent specifications for pharmaceutical and research use. Certificates of Analysis (COA) detailing all test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Loss on Drying	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.