Description

(E)-2-Methyl-2-Butenoic Acid [(3As)-2,3,3Aα,4,4A,5,7Aα,8,9,9Aα-Decahydro-9β-Hydroxy-4Aβ,8α-Dimethyl-3-Methylene-2,5-Dioxoazuleno[6,5-B]Furan-4α-Yl] Ester is a complex, high-purity sesquiterpene lactone derivative with significant biological activity. This specialized intermediate is critical for advanced pharmaceutical research and synthesis, particularly in the development of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of anti-inflammatory and anti-cancer compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel sesquiterpene lactone-based drug candidates.
• Anti-inflammatory Research: Used in the development and study of compounds targeting inflammatory pathways.
• Oncology Drug Discovery: Serves as a precursor for potential chemotherapeutic agents due to its complex lactone structure.
• Natural Product Synthesis: Employed in the semi-synthesis or total synthesis of complex natural products and their analogs.
• Biochemical Research: Utilized as a standard or probe in studies investigating biological mechanisms and structure-activity relationships (SAR).
• Advanced Organic Synthesis: Acts as a sophisticated chiral template or intermediate for constructing complex molecular architectures.

Basic Information

Item	Information
Product Name	(E)-2-Methyl-2-Butenoic Acid [(3As)-2,3,3Aα,4,4A,5,7Aα,8,9,9Aα-Decahydro-9β-Hydroxy-4Aβ,8α-Dimethyl-3-Methylene-2,5-Dioxoazuleno[6,5-B]Furan-4α-Yl] Ester
CAS No.	26305-86-2
Molecular Formula	C₂₁H₂₈O₆
Molecular Weight	376.45 g/mol
Synonyms	Alantolactone 2-methylbut-2-enoate; (E)-2-Methylcrotonic acid alantolactone ester; Isoalantolactone angelate; Helenin angelate derivative; 1(10),4,11(13)-Germacratrien-12,6-olide, 8-angeloyloxy-; 8α-Angeloyloxyisoalantolactone; 8-Angeloyloxyisoalantolactone; (3aR,4S,4aR,7aS,8R,9aR)-8-[(2E)-2-Methylbut-2-enoyl]oxy-4a,8-dimethyl-3-methylidene-2,5-dioxo-3a,4,4a,5,7a,8,9,9a-octahydroazuleno[6,5-b]furan-4-yl acetate (related structure).
EINECS	Contact for details

Quality Control

Our (E)-2-Methyl-2-Butenoic Acid [(3As)-2,3,3Aα,4,4A,5,7Aα,8,9,9Aα-Decahydro-9β-Hydroxy-4Aβ,8α-Dimethyl-3-Methylene-2,5-Dioxoazuleno[6,5-B]Furan-4α-Yl] Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.