Description

Tolmetin is a non-steroidal anti-inflammatory drug (NSAID) belonging to the pyrrole acetic acid class, primarily recognized for its potent cyclooxygenase (COX) inhibitory activity. This compound is a critical active pharmaceutical ingredient (API) valued for its efficacy in managing inflammation and pain. It is essential for pharmaceutical manufacturers and research institutions focused on developing analgesic and anti-inflammatory formulations. Tolmetin CAS NO 26171-23-3 is supplied under stringent quality controls to meet the exacting standards of the global pharmaceutical supply chain.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription and over-the-counter anti-inflammatory and analgesic medications.
• Analgesic Formulations: Used in the development of drugs for the relief of mild to moderate pain, including headaches and musculoskeletal discomfort.
• Anti-inflammatory Therapeutics: Key component in treatments for chronic inflammatory conditions such as rheumatoid arthritis and osteoarthritis.
• Antipyretic Medications: Incorporated into formulations aimed at reducing fever.
• Pharmaceutical Research & Development: Serves as a reference standard and a building block in preclinical and clinical studies for new NSAID derivatives.
• Veterinary Medicine: Applied in anti-inflammatory treatments for companion and livestock animals.

Basic Information

Product Name	Tolmetin
CAS No.	26171-23-3
Molecular Formula	C15H15NO3
Molecular Weight	257.29 g/mol
Synonyms	1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid; Tolectin; McN-2559; 26171-23-3; Tolmetinum; Tolmetina; (1-Methyl-5-(p-toluoyl)pyrrol-2-yl)acetic acid
EINECS	247-491-7

Quality Control

Our Tolmetin is manufactured and tested to meet the highest pharmacopeial standards, including USP and ICH guidelines. Every batch undergoes comprehensive analytical testing to ensure identity, purity, strength, and composition. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, residual solvents, and other critical parameters. Our quality management system is designed to ensure full traceability and compliance with cGMP principles for global pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Microbiological Enumeration	Meets USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.