Description

Naproxen Sodium is the sodium salt form of the widely used non-steroidal anti-inflammatory drug (NSAID) naproxen. This compound is valued for its enhanced solubility and rapid absorption compared to the free acid form, making it a critical active pharmaceutical ingredient (API) for effective pain and inflammation management. It is primarily required by pharmaceutical manufacturers for the production of over-the-counter (OTC) and prescription analgesic and anti-inflammatory medications, targeting conditions such as arthritis, muscle pain, and migraines.

Application

• Pharmaceutical API: Primary use as the active ingredient in solid oral dosage forms, including tablets and capsules, for analgesic and anti-inflammatory therapies.
• Analgesic Formulations: Key component in medications designed for the relief of mild to moderate pain, such as headaches, backaches, and dental pain.
• Anti-inflammatory Medications: Used in treatments for chronic inflammatory conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
• Antipyretic Products: Incorporated into formulations aimed at reducing fever.
• Migraine Relief: Found in specific OTC and prescription products formulated for migraine and tension-type headache relief.
• Generic Drug Manufacturing: A fundamental raw material for the production of generic naproxen sodium medications, ensuring cost-effective healthcare solutions.
• Veterinary Pharmaceuticals: Potential application in veterinary medicine for pain and inflammation management in animals.
• Research & Development: Serves as a reference standard and starting material in pharmaceutical R&D for novel drug delivery systems.

Basic Information

Product Name	Naproxen Sodium
CAS No.	26159-34-2
Molecular Formula	C14H13NaO3
Molecular Weight	252.24 g/mol
Synonyms	(+)-Sodium 6-methoxy-α-methyl-2-naphthaleneacetate; Sodium naproxen; Naproxen Na; Naprosyn Sodium; Aleve (brand name ingredient); Anaprox; Anaprox DS; EC 1.14.99.1 inhibitor; COX inhibitor sodium salt; 2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, sodium salt, (S)-
EINECS	Contact for details

Quality Control

Our Naproxen Sodium is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Every batch undergoes comprehensive analytical testing including assay, impurity profiling, and residual solvent analysis to ensure it meets stringent specifications for pharmaceutical use. A Certificate of Analysis (COA) is provided with each shipment to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
pH (5% solution)	8.0 - 10.0
Specific Rotation	+66.0° to +69.0° (c=1 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.