Description

Nimbolide CAS NO 25990-37-8 is a potent bioactive limonoid triterpenoid primarily isolated from the neem tree (*Azadirachta indica*). This compound is of significant commercial and research interest due to its well-documented anti-proliferative, anti-inflammatory, and chemopreventive properties. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for pharmaceutical R&D, nutraceutical formulation, and advanced life science research.

Application

• Pharmaceutical Research & Development: Serves as a high-purity reference standard and key intermediate in the development of novel anti-cancer and anti-inflammatory therapeutics.
• Nutraceutical & Dietary Supplement Formulation: Used as a standardized bioactive component in advanced herbal and wellness products leveraging neem extracts.
• Life Science & Biochemical Research: Employed as a precise tool compound in cell biology studies to investigate apoptosis, NF-κB signaling pathways, and other molecular mechanisms.
• Cosmeceutical Applications: Incorporated into premium skincare formulations for its anti-inflammatory and antioxidant benefits.
• Agrochemical Research: Studied for its natural pesticidal and insect growth regulation properties in the development of bio-based crop protection agents.

Basic Information

Product Name	Nimbolide
CAS No.	25990-37-8
Molecular Formula	C27H30O7
Molecular Weight	466.52 g/mol
Synonyms	Nimbolide; (2aR,4aS,5aR,6S,7aS,8S,10aS,10bS,10cS)-6-(2-Furanyl)-2a,4a,5,5a,6,7,7a,8,10a,10b,10c-undecahydro-8,10a-dihydroxy-2a,5a,8-trimethyl-9-oxo-4H,9H-naphtho[2',1':4,5]indeno[1,2-b]furan-4-carboxylic acid δ-lactone; Azadirachtin B; 1H,7H-Naphtho[1,8-bc:4,4a-c']difuran-7-one, 2,3,6,6a,7,8,9,9a,9b,10,11,11a-dodecahydro-4-hydroxy-6,6a,10,10-tetramethyl-, (6aS,9aS,9bR,10R,11aR)-
EINECS	Contact for details

Quality Control

Our Nimbolide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.