Description

3-(p-Fluorobenzoyl)-6-Methoxy-2-Methyl-1H-Indole-1-Acetic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate with the CAS number 25803-21-8. This compound is critical for the synthesis of advanced pharmaceutical actives, offering a reliable building block for targeted drug development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the production of novel anti-inflammatory and analgesic agents.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the manufacture of non-steroidal anti-inflammatory drugs (NSAIDs).
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new therapeutic compounds targeting inflammation and pain.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core structural component in multi-step synthesis routes for final drug substances.
• Biochemical Research: Employed in studies investigating cyclooxygenase (COX) enzyme inhibition mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of pharmaceutical products.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and method validation in pharmaceutical labs.

Basic Information

Product Name	3-(p-Fluorobenzoyl)-6-Methoxy-2-Methyl-1H-Indole-1-Acetic Acid
CAS No.	25803-21-8
Molecular Formula	C19H16FNO4
Molecular Weight	341.34 g/mol
Synonyms	6-Methoxy-2-methyl-3-(4-fluorobenzoyl)-1H-indole-1-acetic acid; 3-(4-Fluorobenzoyl)-6-methoxy-2-methyl-1H-indole-1-acetic acid; 1-Acetic acid, 3-(p-fluorobenzoyl)-6-methoxy-2-methyl-1H-indole; 25803-21-8; Fluorobenzoyl Methoxy Methyl Indole Acetic Acid; Indomethacin Fluorinated Analog Intermediate; NSAID Intermediate
EINECS	Contact for details

Quality Control

Our 3-(p-Fluorobenzoyl)-6-Methoxy-2-Methyl-1H-Indole-1-Acetic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.