Description

L-Threo-Sphingosine is a vital bioactive sphingolipid metabolite and a key chiral building block in synthetic chemistry. This compound serves as a fundamental precursor in the biosynthesis of complex sphingolipids and ceramides, which are crucial for cellular membrane structure and signaling pathways. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors, particularly for studying cell apoptosis, proliferation, and for the development of novel therapeutics targeting metabolic and signaling disorders.

Application

• Pharmaceutical Intermediates: Critical chiral precursor for the synthesis of sphingolipid-based drugs, immunosuppressants, and enzyme inhibitors.
• Biochemical Research: Used as a standard and reagent in studies of sphingolipid metabolism, cell signaling, apoptosis, and autophagy.
• Cell Biology Studies: Employed to investigate the role of ceramide and sphingosine-1-phosphate (S1P) pathways in inflammation, cancer, and neurodegenerative diseases.
• Enzyme Substrate/Inhibitor: Serves as a substrate for kinases (e.g., sphingosine kinase) and a precursor for inhibitors targeting these enzymes.
• Cosmeceutical R&D: Investigated for its role in skin barrier function and as a potential active ingredient in dermatological formulations.
• Reference Standard: High-purity grade used as a certified reference material (CRM) for analytical method development and quality control in related industries.

Basic Information

Product Name	L-Threo-Sphingosine
CAS No.	25695-95-8
Molecular Formula	C18H37NO2
Molecular Weight	299.50 g/mol
Synonyms	(2S,3R)-2-Amino-1,3-octadecanediol; D-erythro-Sphingosine (enantiomer); (2S,3R)-Sphingosine; Sphing-4-enine; Sphingenine; trans-4-Sphingenine; 4-trans-Sphingenine; (E)-Sphing-4-enine
EINECS	Contact for details

Quality Control

Our L-Threo-Sphingosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and the absence of critical impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container must be sealed under dry conditions and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Threo isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.