Description

Bis(Trimethylsilyl)Trifluoroacetamide is a highly reactive organosilicon derivatization agent, primarily used as a powerful silyl donor in analytical chemistry. Its core value lies in its ability to effectively and rapidly silylate a wide range of active hydrogen-containing compounds, such as alcohols, phenols, carboxylic acids, and amines, for gas chromatographic (GC) analysis. This compound is essential for laboratories and industries requiring precise and sensitive analytical methods. Key users include pharmaceutical R&D, environmental testing labs, petrochemical analysis, and forensic science facilities.

Application

• Gas Chromatography (GC) Derivatization: Primary reagent for converting polar, non-volatile compounds into volatile, thermally stable trimethylsilyl (TMS) derivatives for analysis.
• Pharmaceutical Analysis: Used in the quantification and profiling of drug metabolites, steroids, and other bioactive molecules.
• Metabolomics and Biomarker Discovery: Critical for preparing biological samples (urine, plasma, tissue extracts) for GC-MS profiling.
• Forensic Toxicology: Employed in the derivatization of drugs of abuse and their metabolites for confirmatory testing.
• Environmental Analysis: Facilitates the detection of pesticides, herbicides, and phenolic pollutants in water and soil samples.
• Polymer and Petrochemical Research: Used to analyze additives, catalysts, and degradation products.
• Carbohydrate and Sugar Analysis: Effective silylating agent for monosaccharides and disaccharides.
• Organic Synthesis: Acts as a protecting group reagent and a source of the trifluoroacetamido moiety in specialized synthetic routes.

Basic Information

Product Name	Bis(Trimethylsilyl)Trifluoroacetamide
CAS No.	25561-30-2
Molecular Formula	C8H18F3NOSi2
Molecular Weight	257.40 g/mol
Synonyms	BSTFA; N,O-Bis(trimethylsilyl)trifluoroacetamide; BSA Related Derivatization Agent; Trifluoro-N,N-bis(trimethylsilyl)acetamide; 1,1,1-Trifluoro-N-(trimethylsilyl)-N-(trimethylsilyl)acetamide; TMS Derivative Reagent; Silylation Reagent BSTFA; Derivatization Grade BSTFA
EINECS	247-089-1

Quality Control

Our Bis(Trimethylsilyl)Trifluoroacetamide is manufactured under strict quality systems to ensure batch-to-batch consistency and high reactivity for derivatization. Each lot is tested to meet exacting specifications for purity and performance. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing assay, impurity profile, and suitability for GC applications. We support compliance with cGMP, ISO, and other relevant quality frameworks for analytical and research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain efficacy. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Refractive Index (n20D)	1.380 - 1.390
Density (g/mL at 25°C)	0.950 - 0.970
Suitability for Derivatization	Passes performance test

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.