Description

H2N-PEG-NH2 is a bifunctional amine-terminated polyethylene glycol derivative, a crucial building block in advanced material synthesis. This compound matters for its ability to introduce hydrophilic PEG spacers and reactive amine groups, enabling precise conjugation and modification of biomolecules and surfaces. Industries such as bioconjugation, pharmaceutical development, and nanotechnology rely on it for creating targeted drug delivery systems, diagnostic agents, and functional hydrogels.

Application

• Bioconjugation Linker: Used to crosslink proteins, peptides, or antibodies with other molecules, drugs, or surfaces while improving solubility and reducing immunogenicity.
• PEGylation Reagent: Serves as a key intermediate in the PEGylation of therapeutic proteins and peptides to enhance their pharmacokinetic profiles.
• Polymer & Hydrogel Synthesis: Acts as a difunctional monomer or crosslinker for creating biocompatible PEG-based polymers, networks, and hydrogels for biomedical applications.
• Surface Functionalization: Employed to amine-functionalize nanoparticles, quantum dots, and other material surfaces for subsequent bioconjugation or further chemical modification.
• Diagnostic Probe Development: Facilitates the attachment of targeting ligands and reporter molecules (e.g., fluorophores) in the development of diagnostic assays and imaging probes.
• Drug Delivery System Fabrication: A critical component in constructing dendrimers, micelles, and other nanocarriers for controlled and targeted drug release.

Basic Information

Product Name	H2N-PEG-NH2
CAS No.	24991-53-5
Molecular Formula	C2n+4H4n+10N2On+1 (n = PEG repeat units)
Molecular Weight	Variable (dependent on PEG chain length; e.g., ~1,000, ~2,000, ~3,400, ~5,000, ~10,000 Da)
Synonyms	alpha,ω-Diamino polyethylene glycol; Bis(2-aminoethyl) ether polyethylene glycol; Poly(oxy-1,2-ethanediyl), alpha,ω-diamino; PEG diamine; Diamino-PEG; Jeffamine EDR series (related); O,O'-Bis(2-aminoethyl)polyethylene glycol; Polyethylene glycol bis(amine); NH2-PEG-NH2
EINECS	Contact for details

Quality Control

Our H2N-PEG-NH2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and HPLC for structural confirmation and purity assessment, to ensure consistency and compliance with industry standards. Certificates of Analysis (COA) detailing purity, molecular weight, and functional group content are available upon request. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent moisture absorption and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Molecular Weight (Average)	As per ordered grade (e.g., 1k, 2k, 3.4k, 5k, 10k Da)
Purity (HPLC)	≥ 95%
Amine Value	As per theoretical value for specified MW
Water Content (KF)	≤ 1.0%
Residual Solvent (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.