Description

trans-1,2,5-Trimethylpiperazine is a high-purity, stereochemically defined piperazine derivative, a critical building block in advanced organic synthesis. Its value lies in its rigid, substituted cyclic diamine structure, which serves as a key chiral intermediate and ligand scaffold for pharmaceutical and fine chemical manufacturing. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemistry and reliable quality for developing active ingredients and catalysts.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of complex drug molecules, particularly in central nervous system (CNS) agents and antiviral medications.
• Catalyst Ligand Precursor: Used in the preparation of asymmetric catalysts for enantioselective synthesis, enabling the production of single-isomer compounds.
• Agrochemical Synthesis: Serves as an intermediate in the development of novel pesticides and herbicides with specific stereochemical requirements.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, dyes, and complex organic compounds where its methylated piperazine core is integral.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and structure-activity relationships.
• Polymer Modification: Can be utilized as a monomer or cross-linking agent in the synthesis of specialty polymers with tailored properties.

Basic Information

Product Name	trans-1,2,5-Trimethylpiperazine
CAS No.	24779-49-5
Molecular Formula	C7H16N2
Molecular Weight	128.22 g/mol
Synonyms	(1R,2S,5S)-1,2,5-Trimethylpiperazine; (1S,2R,5R)-1,2,5-Trimethylpiperazine; trans-1,2,5-TMP; 1,2,5-Trimethylpiperazine (trans isomer); Piperazine, 1,2,5-trimethyl-, (1R,2S,5S)-rel-; rel-(1R,2S,5S)-1,2,5-Trimethylpiperazine
EINECS	Contact for details

Quality Control

Our trans-1,2,5-Trimethylpiperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by GC or HPLC, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific parameters. We support compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Chiral Purity (trans isomer)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.