Description

n-Methyl-n-(Trimethylsilyl)Trifluoroacetamide is a highly reactive silylating agent and derivatization reagent essential for analytical chemistry. Its primary value lies in its ability to effectively protect sensitive functional groups, such as hydroxyls and amines, by converting them into stable, volatile trimethylsilyl (TMS) derivatives for gas chromatography (GC) and mass spectrometry (MS) analysis. This compound is a critical tool for analytical chemists, researchers, and quality control laboratories in the pharmaceutical, environmental, forensic, and metabolomics sectors, where precise compound identification and quantification are paramount.

Application

• Derivatization for Gas Chromatography (GC): Used to convert polar, non-volatile compounds (e.g., sugars, organic acids, steroids, drugs of abuse) into volatile TMS derivatives for accurate GC and GC-MS analysis.
• Metabolite Profiling (Metabolomics): Essential for preparing biological samples (urine, plasma, tissue extracts) to enable comprehensive profiling of small molecule metabolites.
• Pharmaceutical Impurity Analysis: Employed in the derivatization of active pharmaceutical ingredients (APIs) and their related substances to enhance detection and separation during purity testing.
• Environmental Analysis: Facilitates the detection and quantification of trace-level pollutants, pesticides, and phenols in water and soil samples.
• Forensic Toxicology: A key reagent for the preparation of drugs and their metabolites from biological matrices prior to confirmatory analysis.
• Protecting Group in Organic Synthesis: Serves as a versatile reagent for introducing the trimethylsilyl group in multi-step synthetic pathways.
• Carbohydrate Analysis: Used to derivative complex sugars and glycans for structural elucidation and quantification.

Basic Information

Product Name	n-Methyl-n-(Trimethylsilyl)Trifluoroacetamide
CAS No.	24589-78-4
Molecular Formula	C7H14F3NOSi
Molecular Weight	201.28 g/mol
Synonyms	MSTFA; N-Methyl-N-trimethylsilyltrifluoroacetamide; Methyl(trimethylsilyl)amino trifluoroacetate; N-Methyl-N-(trimethylsilyl)-2,2,2-trifluoroacetamide; N-Methyl-N-(trimethylsilyl)trifluoroacetamide; Trimethylsilylating Agent MSTFA; TMS derivative reagent MSTFA; (Trimethylsilyl)methylamino trifluoroacetate
EINECS	Contact for details

Quality Control

Our n-Methyl-n-(Trimethylsilyl)Trifluoroacetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity, identity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions, preferably in a glove box or under a dry inert atmosphere (e.g., nitrogen or argon) to maintain optimal reactivity and shelf life.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Refractive Index (n20D)	1.380 - 1.390
Density (20°C)	1.10 - 1.15 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.