Description

3-(p-Chlorophenyl)-3-Phenyl-1-[4-(p-Tolyl)-1-Piperazinyl]-1-Propanone is a high-purity, advanced pharmaceutical intermediate with a complex piperazine-based structure. This compound matters for its role as a critical building block in the synthesis of specialized active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop and scale up production of novel therapeutic agents, ensuring process consistency and final product quality.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel psychoactive substances and CNS-targeting drug candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Synthesis: Serves as a specialized building block for constructing complex molecules with specific pharmacological profiles.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for studying piperazine derivative chemistry and biological activity.

Basic Information

Product Name	3-(p-Chlorophenyl)-3-Phenyl-1-[4-(p-Tolyl)-1-Piperazinyl]-1-Propanone
CAS No.	23904-72-5
Molecular Formula	C26H25ClN2O
Molecular Weight	416.94 g/mol
Synonyms	1-[4-(4-Methylphenyl)-1-piperazinyl]-3-(4-chlorophenyl)-3-phenyl-1-propanone; 3-(4-Chlorophenyl)-3-phenyl-1-[4-(4-methylphenyl)-1-piperazinyl]-1-propanone; 3-(p-Chlorophenyl)-3-phenyl-1-[4-(p-tolyl)piperazin-1-yl]propan-1-one; L-741,626 (common research code); 23904-72-5; 3-(4-Chlorophenyl)-1-[4-(4-methylphenyl)-1-piperazinyl]-3-phenyl-1-propanone
EINECS	Contact for details

Quality Control

Our 3-(p-Chlorophenyl)-3-Phenyl-1-[4-(p-Tolyl)-1-Piperazinyl]-1-Propanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.