Description

2-Propenoyl Chloride, 3-(3,4-Dihydroxyphenyl)- is a specialized acryloyl chloride derivative, also known as caffeoyl chloride, which serves as a key reactive intermediate for introducing the caffeoyl moiety into target molecules. This compound is critical for researchers and manufacturers requiring high-purity building blocks for advanced organic synthesis and pharmaceutical development. It is primarily utilized in the synthesis of bioactive compounds, including antioxidants, enzyme inhibitors, and novel pharmaceutical candidates, making it essential for the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing potential drug candidates, particularly those targeting oxidative stress and inflammation.
• Antioxidant Research: Used to create ester and amide derivatives of caffeic acid for studying structure-activity relationships in antioxidant compounds.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for creating functional polymers with specific phenolic properties.
• Bioconjugation: Employed to attach the caffeoyl group to peptides, proteins, or other biomolecules for probe or drug delivery system development.
• Agrochemical Synthesis: Intermediate in the production of novel pesticides or plant growth regulators that leverage its phenolic structure.
• Cosmetic Ingredient Synthesis: Used to manufacture UV-absorbing or anti-aging compounds for advanced skincare formulations.
• Material Science: Precursor for surface modification of materials to impart antioxidant or antimicrobial properties.
• Chemical Biology Probes: Synthesis of activity-based probes for studying enzymes like transferases that act on phenolic substrates.

Basic Information

Product Name	2-Propenoyl Chloride, 3-(3,4-Dihydroxyphenyl)-
CAS No.	23416-69-5
Molecular Formula	C9H7ClO3
Molecular Weight	198.60 g/mol
Synonyms	Caffeoyl Chloride; 3,4-Dihydroxycinnamoyl Chloride; (E)-3-(3,4-Dihydroxyphenyl)acryloyl Chloride; 3-(3,4-Dihydroxyphenyl)propenoyl Chloride; 3,4-Dihydroxy-trans-cinnamoyl Chloride; Chlorure de cafféoyle (French); Caffeic Acid Chloride
EINECS	Contact for details

Quality Control

Our 2-Propenoyl Chloride, 3-(3,4-Dihydroxyphenyl)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). Keep the container in a cool, dry, and well-ventilated place, away from incompatible materials such as strong bases, oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Anhydrous basis)
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.