Description

3-Hydroxyglibenclamide is a key pharmaceutical intermediate and metabolite of the sulfonylurea drug glibenclamide. This compound is essential for research and development in metabolic disease studies, particularly in understanding drug action and pharmacokinetics. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers of active pharmaceutical ingredients (APIs) for quality control and metabolic pathway investigation.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development and validation in drug testing.
• Metabolite Studies: Critical for in-vitro and in-vivo research on the metabolism, pharmacokinetics, and pharmacodynamics of the antidiabetic drug glibenclamide.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a synthetic building block in the production and purification of related sulfonylurea compounds.
• Biochemical Research: Employed in studies investigating pancreatic β-cell function, ATP-sensitive potassium (KATP) channels, and insulin secretion mechanisms.
• Quality Control & Assurance: Acts as an impurity standard to monitor and control the quality of glibenclamide API batches during manufacturing.

Basic Information

Product Name	3-Hydroxyglibenclamide
CAS No.	23074-07-9
Molecular Formula	C23H28ClN3O6S
Molecular Weight	510.00 g/mol
Synonyms	3-Hydroxy Glyburide; 1-[4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenyl]sulfonyl]-3-(3-hydroxycyclohexyl)urea; 3-Hydroxyglibenclamide; 3-OH-Glibenclamide; Glibenclamide 3-Hydroxy Metabolite; 3-Hydroxy Glybenclamide; 3-Hydroxyglibenclamide (Glyburide Metabolite)
EINECS	Contact for details

Quality Control

Our 3-Hydroxyglibenclamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with ICH guidelines and GLP practices.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at 2-8°C to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.