Description

Glibenclamide Potassium Salt is the potassium salt form of the widely used second-generation sulfonylurea. This compound is a critical active pharmaceutical ingredient (API) valued for its potent hypoglycemic activity, which makes it essential for the development of specific therapeutic formulations. It is primarily required by pharmaceutical manufacturers and research institutions engaged in metabolic disorder research and drug development.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of oral anti-diabetic medications for Type 2 Diabetes Mellitus.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for drug assay and impurity profiling.
• Biochemical Research: Utilized in pharmacological and metabolic studies to investigate sulfonylurea receptor (SUR) activity and insulin secretion mechanisms.
• Formulation Development: Employed in pre-formulation and formulation studies for developing stable and bioavailable solid dosage forms like tablets.
• Metabolite Synthesis: Acts as a key starting material or intermediate in the synthetic pathways for related metabolites or derivatives.

Basic Information

Product Name	Glibenclamide Potassium Salt
CAS No.	23047-14-5
Molecular Formula	C23H28ClKN3O5S
Molecular Weight	533.10 g/mol
Synonyms	Glyburide Potassium Salt; 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide Potassium Salt; 1-[[p-[2-(5-Chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea Potassium Salt; N-[4-[β-(2-Methoxy-5-chlorobenzamido)ethyl]benzenesulfonyl]-N′-cyclohexylurea Potassium Salt; Glibenclamide K Salt; Euglucon Potassium Salt; Daonil Potassium Salt
EINECS	Contact for details

Quality Control

Our Glibenclamide Potassium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤2.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.