Description

(Z)-2-Methyl-2-Butenoic Acid [(3Ar,4Aα,9Aα)-Dodecahydro-6β-Hydroxy-8Aβ-Methyl-3,5-Bis(Methylene)-2-Oxonaphtho[2,3-B]Furan-7α-Yl] Ester is a complex, high-purity synthetic intermediate characterized by its specific stereochemistry and functional groups. This compound is of significant value in advanced organic synthesis, particularly for constructing intricate molecular architectures found in pharmaceuticals and specialty chemicals. It is primarily sought by research institutions and industrial R&D departments engaged in the development of novel active pharmaceutical ingredients (APIs), complex natural product analogs, and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex, biologically active molecules and novel drug candidates.
• Advanced Organic Synthesis: Used in stereoselective reactions to construct intricate polycyclic frameworks and introduce specific functional groups.
• Natural Product Analog Development: Serves as a precursor in the semi-synthesis or total synthesis of complex natural products and their derivatives for biological evaluation.
• Fine Chemical Production: Employed in the manufacture of high-value specialty chemicals requiring precise stereochemical control.
• Academic & Industrial Research: A valuable tool for methodological development in synthetic organic chemistry and catalysis studies.

Basic Information

Product Name	(Z)-2-Methyl-2-Butenoic Acid [(3Ar,4Aα,9Aα)-Dodecahydro-6β-Hydroxy-8Aβ-Methyl-3,5-Bis(Methylene)-2-Oxonaphtho[2,3-B]Furan-7α-Yl] Ester
CAS No.	22850-61-9
Molecular Formula	C₂₁H₂₈O₅
Molecular Weight	360.45 g/mol
Synonyms	(Z)-Tiglic Acid [(3Ar,4Aα,9Aα)-Dodecahydro-6β-Hydroxy-8Aβ-Methyl-3,5-Bis(Methylene)-2-Oxonaphtho[2,3-B]Furan-7α-Yl] Ester; Tiglate Ester of a Decalin-Fused Lactone; 2-Methyl-(Z)-2-butenoic acid ester with a polycyclic lactone alcohol; (3aR,4aS,9aS,9bR)-Dodecahydro-6-hydroxy-8a-methyl-3,5-bis(methylene)-2-oxonaphtho[2,3-b]furan-7-yl (2Z)-2-methylbut-2-enoate; Polycyclic Lactone Tiglate; Contact for additional aliases.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and stereochemical integrity. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.