Description

8-Methyl-8-Azabicyclo[3.2.1]Oct-3-Yl [1Alpha,3Alpha(E),5Alpha]-2-Methyl-2-Butenoate Hydrobromide is a high-purity, complex organic salt with significant pharmacological relevance. This compound is valued for its precise stereochemistry and serves as a critical intermediate in advanced pharmaceutical synthesis. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of active pharmaceutical ingredients (APIs) and novel therapeutic agents. Consistent quality and reliable supply are paramount for its application in high-value chemical production.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system.
• Medicinal Chemistry Research: Used as a precursor or reference standard in drug discovery and development programs for structure-activity relationship (SAR) studies.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for commercial pharmaceutical manufacturing.
• Analytical Standard: Serves as a high-purity standard for method development and quality control in analytical laboratories (HPLC, GC, NMR).
• Biochemical Research: Potential use in studying specific receptor interactions and biochemical pathways due to its structural features.
• Fine Chemical Synthesis: Intermediate for the preparation of other specialized fine chemicals and complex organic molecules.

Basic Information

Product Name	8-Methyl-8-Azabicyclo[3.2.1]Oct-3-Yl [1Alpha,3Alpha(E),5Alpha]-2-Methyl-2-Butenoate Hydrobromide
CAS No.	22846-83-9
Molecular Formula	C14H24BrNO2
Molecular Weight	318.25 g/mol
Synonyms	3-Tigloyloxy-8-methyl-8-azabicyclo[3.2.1]octane Hydrobromide; Tropine Tiglate Hydrobromide; 8-Methyl-8-azabicyclo[3.2.1]octan-3-yl (E)-2-methylbut-2-enoate hydrobromide; 3α-Tigloyloxytropane Hydrobromide; (1R,3r,5S)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl (E)-2-methylbut-2-enoate hydrobromide; Nortropine Tiglate Hydrobromide (related); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 8-Methyl-8-Azabicyclo[3.2.1]Oct-3-Yl [1Alpha,3Alpha(E),5Alpha]-2-Methyl-2-Butenoate Hydrobromide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results from tests including HPLC assay, chiral purity, residual solvents, and related substances. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.