Description

4-Phosphonooxy-Tempo Hydrate is a stable nitroxide radical derivative, specifically a phosphorylated analog of the TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl) radical. This compound is valued for its dual functionality, combining the properties of a persistent radical with a phosphonooxy group, making it a versatile intermediate and reagent in advanced chemical synthesis and materials science. It is primarily utilized by researchers and manufacturers in the pharmaceutical, polymer, and specialty chemical industries for applications ranging from controlled radical polymerization to spin labeling and as a catalyst or mediator in oxidation reactions.

Application

• Controlled/Living Radical Polymerization (ATRP, NMP): Acts as a nitroxide mediator or initiator for the synthesis of polymers with controlled molecular weight and architecture.
• Spin Labeling and EPR Spectroscopy: Used as a stable spin probe for studying molecular dynamics, structure, and interactions in biological systems and soft materials.
• Organic Synthesis & Catalysis: Serves as a catalyst or co-catalyst in selective oxidation reactions of alcohols and other organic substrates.
• Polymer Stabilization: Functions as an antioxidant or radical scavenger to inhibit degradation in polymers and other sensitive materials.
• Bioconjugation and Probe Development: The phosphonooxy group provides a handle for conjugation to biomolecules, creating labeled probes for imaging or diagnostic applications.
• Advanced Material Research: Employed in the development of functional surfaces, conductive polymers, and other novel materials where nitroxide chemistry is advantageous.

Basic Information

Product Name	4-Phosphonooxy-Tempo Hydrate
CAS No.	22690-04-6
Molecular Formula	C9H20NO5P • xH2O
Molecular Weight	253.24 (Anhydrous basis)
Synonyms	4-Hydroxy-TEMPO phosphate; 4-Phosphonooxy-2,2,6,6-tetramethylpiperidine-1-oxyl hydrate; 4-(Dihydroxyphosphoryl)oxy-TEMPO; TEMPO-4-phosphate; 1-Oxyl-2,2,6,6-tetramethyl-4-piperidinyl phosphate; 4-PO-TEMPO; 4-Phosphoryloxy-TEMPO hydrate; 2,2,6,6-Tetramethyl-4-piperidinol-1-oxyl phosphate ester
EINECS	Contact for details

Quality Control

Our 4-Phosphonooxy-Tempo Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity, and consistency. Key parameters monitored include assay (by HPLC or titration), radical content (by EPR or redox titration), and control of related substances. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your R&D and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent absorption of moisture. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	Orange to red powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Radical Content (EPR/Titration)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solubility	Soluble in water, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.