Description

[3Ar,4Aα,9Aβ,(+)]-4α-Acetoxydodecahydro-8β-Hydroxy-8Aβ-Methyl-3,5-Bis(Methylene)Naphtho[2,3-B]Furan-2-One is a complex, high-purity sesquiterpene lactone derivative with a defined stereochemistry. This compound matters as a sophisticated chemical intermediate and research standard for the development of novel bioactive molecules. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on synthetic chemistry and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex natural product analogs and potential therapeutic agents.
• Medicinal Chemistry Research: Used as a reference standard or starting material for structure-activity relationship (SAR) studies targeting specific biological pathways.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses requiring a specific, functionalized sesquiterpene core structure.
• Academic & Institutional Research: Utilized in university and laboratory settings for chemical methodology development and natural product synthesis projects.
• Biochemical Tool Compound: Investigated for its potential biological activity in various assay systems due to its lactone functional group.
• Process Development: Acts as a model compound for scaling up challenging synthetic routes under cGMP or other controlled environments.

Basic Information

Product Name	[3Ar,4Aα,9Aβ,(+)]-4α-Acetoxydodecahydro-8β-Hydroxy-8Aβ-Methyl-3,5-Bis(Methylene)Naphtho[2,3-B]Furan-2-One
CAS No.	22553-66-8
Molecular Formula	C20H26O5
Molecular Weight	346.42 g/mol
Synonyms	(+)-4α-Acetoxy-8β-hydroxy-8aβ-methyldodecahydro-3,5-bis(methylene)naphtho[2,3-b]furan-2-one; 4α-Acetoxy-8β-hydroxy-8aβ-methyl-3,5-bis(methylene)perhydronaphtho[2,3-b]furan-2-one; 8β-Hydroxy-4α-acetoxy-8aβ-methyl-3,5-bis(methylene)perhydronaphtho[2,3-b]furan-2-one; A sesquiterpene lactone derivative; Parthenolide analog derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our [3Ar,4Aα,9Aβ,(+)]-4α-Acetoxydodecahydro-8β-Hydroxy-8Aβ-Methyl-3,5-Bis(Methylene)Naphtho[2,3-B]Furan-2-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets exacting research-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and reproducibility for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be sensitive to moisture and prolonged exposure to air; store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.