Description

(3Ar,4S,6Z,10Z,11Ar)-3A,4,5,8,9,11A-Hexahydro-3-Methylene-6,10-Bis(Hydroxymethyl)-4-Hydroxycyclodeca[B]Furan-2(3H)-One 4-[(Z)-4-Hydroxy-2-Methyl-2-Butenoate] is a complex sesquiterpene lactone derivative with significant biological activity. This compound matters as a key advanced intermediate or reference standard for the research and development of novel pharmaceutical agents, particularly in oncology and immunology. It is primarily needed by R&D chemists, process development scientists, and analytical laboratories in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of complex natural product analogs and novel drug candidates.
• Reference Standard: High-purity material for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Biological Research: Used as a probe or tool compound in biochemical and pharmacological studies to investigate specific biological pathways.
• Process Chemistry: Serves as a key intermediate in scaling up synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: Enables universities and research institutes to study structure-activity relationships (SAR) of sesquiterpene lactones.
• Custom Synthesis: Starting point for the preparation of specialized derivatives for client-specific research programs.

Basic Information

Product Name	(3Ar,4S,6Z,10Z,11Ar)-3A,4,5,8,9,11A-Hexahydro-3-Methylene-6,10-Bis(Hydroxymethyl)-4-Hydroxycyclodeca[B]Furan-2(3H)-One 4-[(Z)-4-Hydroxy-2-Methyl-2-Butenoate]
CAS No.	22419-78-9
Molecular Formula	C21H28O8
Molecular Weight	408.45 g/mol
Synonyms	4-Hydroxy-2-methyl-2-butenoic acid (3aR,4S,6Z,10Z,11aR)-3a,4,5,8,9,11a-hexahydro-3-methylene-6,10-bis(hydroxymethyl)-4-hydroxycyclodeca[b]furan-2(3H)-one ester; Parthenolide derivative; Parthenolide 4-hydroxy-2-methyl-2-butenoate; Germacranolide sesquiterpene lactone ester; (Z)-4-Hydroxy-2-methyl-2-butenoic acid ester of parthenolide analog; 4-Acetoxy-2-methyl-2-butenoic acid parthenolide ester (related); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (3Ar,4S,6Z,10Z,11Ar)-3A,4,5,8,9,11A-Hexahydro-3-Methylene-6,10-Bis(Hydroxymethyl)-4-Hydroxycyclodeca[B]Furan-2(3H)-One 4-[(Z)-4-Hydroxy-2-Methyl-2-Butenoate] is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. For long-term stability, storage at 2-8°C is recommended. Keep the container tightly sealed when not in use to prevent degradation from moisture and oxygen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.