Description

Piperazine-1-Carboxamidine Hemisulfate is a high-purity chemical intermediate of significant importance in advanced organic synthesis. This compound serves as a critical building block for the development of pharmaceuticals and bioactive molecules, particularly those targeting enzyme inhibition. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and life science industries for the synthesis of novel compounds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly protease inhibitors and other enzyme-targeted therapeutics.
• Biochemical Research: Used as a reagent in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Agrochemical Synthesis: Serves as a building block for developing new crop protection agents and pesticides.
• Chemical Biology Probe Development: Employed in the creation of molecular probes to study biological pathways and protein function.
• Peptidomimetic Chemistry: Integral for constructing peptidomimetic scaffolds that mimic natural peptides for enhanced stability and bioavailability.

Basic Information

Product Name	Piperazine-1-Carboxamidine Hemisulfate
CAS No.	22365-47-5
Molecular Formula	C5H13N5 • ½H2SO4
Molecular Weight	199.21 g/mol (free base: 127.19)
Synonyms	1-Piperazinecarboximidamide hemisulfate; Piperazine-1-carboxamidine hemisulfate salt; Guanidine, (1-piperazinyl)-, hemisulfate; (Piperazin-1-yl)formamidine hemisulfate; 1-Piperazinecarboxamidine sulfate (1:0.5); UNII-6J0L8VK55Y; 6J0L8VK55Y; (Piperazin-1-yl)methanimidamide hemisulfate
EINECS	Contact for details

Quality Control

Our Piperazine-1-Carboxamidine Hemisulfate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.