Description

6-Methyloctahydropyrrolo[1,2-A]Pyrazine Dihydrochloride is a high-purity, specialized heterocyclic compound with significant utility in advanced organic synthesis. This dihydrochloride salt form offers enhanced stability and handling properties for critical research and development processes. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for applications in medicinal chemistry and as a sophisticated building block for complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold or precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used as a privileged structure in hit-to-lead optimization and library synthesis for drug discovery programs.
• Peptidomimetics: Functions as a constrained dipeptide mimetic or a proline analogue in the design of bioactive peptides with improved metabolic stability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or catalyst ligand in stereoselective transformations due to its rigid, polycyclic structure.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function or protein-protein interactions.
• Fine Chemical Production: Acts as a high-value building block for the multi-step synthesis of specialty chemicals and advanced materials.

Basic Information

Product Name	6-Methyloctahydropyrrolo[1,2-A]Pyrazine Dihydrochloride
CAS No.	22177-06-6
Molecular Formula	C8H17N3 · 2HCl
Molecular Weight	240.16 g/mol (free base: 155.24 g/mol)
Synonyms	6-Methylhexahydro-1H-pyrrolo[1,2-a]pyrazine dihydrochloride; 6-Methyl-1,2,3,4,6,7,8,8a-octahydropyrrolo[1,2-a]pyrazine dihydrochloride; (6S)-6-Methyloctahydropyrrolo[1,2-a]pyrazine dihydrochloride (if stereospecific); 6-Methylperhydropyrrolo[1,2-a]pyrazine dihydrochloride; L-Proline methyl ester cyclization product dihydrochloride; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our 6-Methyloctahydropyrrolo[1,2-A]Pyrazine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.