Description

18-Hydroxy-5,8,11,14-Eicosatetraenoic Acid CAS NO 21914-83-0 is a hydroxy derivative of arachidonic acid, a key eicosanoid signaling molecule. This compound is of significant interest in biochemical and pharmacological research due to its role as a potential intermediate or regulator in inflammatory and metabolic pathways. It is primarily utilized by research institutions and pharmaceutical development companies for investigating lipid mediators, cell signaling mechanisms, and as a reference standard.

Application

• Biochemical Research: Used as a critical reference standard and intermediate in the study of eicosanoid biosynthesis and metabolism.
• Pharmaceutical R&D: Serves as a key starting material or analytical standard in the development of novel anti-inflammatory or metabolic disorder therapeutics.
• Cell Signaling Studies: Employed in vitro and in vivo to investigate the role of hydroxy-eicosatetraenoic acids (HETEs) in cellular communication and disease models.
• Analytical Chemistry: Used as a high-purity certified reference material (CRM) for method development and validation in LC-MS, GC-MS, and HPLC analyses.
• Enzymology: Acts as a substrate or product in assays for enzymes like cytochrome P450s, lipoxygenases, and cyclooxygenases.

Basic Information

Product Name	18-Hydroxy-5,8,11,14-Eicosatetraenoic Acid
CAS No.	21914-83-0
Molecular Formula	C₂₀H₃₂O₃
Molecular Weight	320.47 g/mol
Synonyms	18-HETE; 18-Hydroxyarachidonic Acid; 18-Hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic Acid; 18-Hydroxy-AA; (5Z,8Z,11Z,14Z)-18-Hydroxyicosa-5,8,11,14-tetraenoic Acid; 18-Hydroxyeicosatetraenoic Acid
EINECS	Contact for details

Quality Control

Our 18-Hydroxy-5,8,11,14-Eicosatetraenoic Acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC and GC-MS, to ensure high purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles. We support research and development with reliable and consistent quality, suitable for demanding analytical and synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term storage, solutions should be prepared in appropriate, anhydrous solvents and kept at -80°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 90.0%
Solubility	Soluble in ethanol, DMSO, and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.