Description

Methyl 6-Chloro-3-Hydroxypyrazine-2-Carboxylate is a high-purity, versatile pyrazine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its functionalized heterocyclic structure, which enables the construction of complex molecules with targeted biological activity. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging its heterocyclic core for enhanced bioactivity.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the multi-step synthesis of complex APIs requiring a functionalized pyrazine moiety.
• Material Science Precursor: Investigated for the synthesis of specialized ligands and organic electronic materials due to its electron-deficient aromatic system.

Basic Information

Product Name	Methyl 6-Chloro-3-Hydroxypyrazine-2-Carboxylate
CAS No.	21874-47-5
Molecular Formula	C6H5ClN2O3
Molecular Weight	188.57 g/mol
Synonyms	6-Chloro-3-hydroxypyrazine-2-carboxylic acid methyl ester; Methyl 6-chloro-3-oxo-3,4-dihydropyrazine-2-carboxylate; 2-Pyrazinecarboxylic acid, 6-chloro-3-hydroxy-, methyl ester; 6-Chloro-3-hydroxy-2-pyrazinecarboxylic acid methyl ester; Methyl 6-chloro-3-hydroxypyrazinecarboxylate; 21874-47-5; Methyl 6-chloro-3-hydroxypyrazine-2-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 6-Chloro-3-Hydroxypyrazine-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports your compliance needs in regulated GMP and ISO-governed environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.