Description

1-Methyl-4-Hydroxy-Piperidine-4-Dicarboxylic Acid Methyl Ester is a high-purity, functionalized piperidine derivative that serves as a critical chiral building block and synthetic intermediate. Its value lies in its unique structure, which incorporates both hydroxyl and ester functionalities on the same carbon, enabling its use in complex organic synthesis and pharmaceutical research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly in developing central nervous system (CNS) agents, receptor modulators, and bioactive alkaloids.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where its piperidine scaffold can contribute to specific biological activity.
• Ligand and Catalyst Precursor: Serves as a starting material for creating sophisticated chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to construct complex natural products and specialty chemicals requiring a functionalized piperidine core.
• Academic & Industrial R&D: A valuable reference standard and building block for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-Methyl-4-Hydroxy-Piperidine-4-Dicarboxylic Acid Methyl Ester
CAS No.	21667-71-0
Molecular Formula	C10H17NO5
Molecular Weight	231.25 g/mol
Synonyms	4-Hydroxy-1-methyl-4-piperidinecarboxylic acid dimethyl ester; Dimethyl 4-hydroxy-1-methylpiperidine-4-carboxylate; 1-Methyl-4-hydroxy-4-piperidinedicarboxylic acid dimethyl ester; 4-Hydroxy-1-methylpiperidine-4,4-dicarboxylic acid dimethyl ester; Methyl 1-methyl-4-hydroxy-4-piperidinecarboxylate; 4-Piperidinecarboxylic acid, 4-hydroxy-1-methyl-, dimethyl ester; 1-Methyl-4-hydroxy-4-(methoxycarbonyl)piperidine-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1-Methyl-4-Hydroxy-Piperidine-4-Dicarboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.