Description

cis-4-(Hydroxymethyl)Piperidin-3-Ol is a versatile chiral piperidine derivative, serving as a crucial building block in advanced organic synthesis. Its bifunctional nature, featuring both hydroxyl and hydroxymethyl groups, makes it a valuable intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for applications in drug discovery and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) drugs, receptor modulators, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides requiring specific stereochemical configurations.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: Incorporated into the backbone of peptide analogs to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects in fine chemical and CDMO (Contract Development and Manufacturing Organization) settings.

Basic Information

Product Name	cis-4-(Hydroxymethyl)Piperidin-3-Ol
CAS No.	21492-03-5
Molecular Formula	C6H13NO2
Molecular Weight	131.17 g/mol
Synonyms	cis-3-Hydroxy-4-piperidinemethanol; (3R,4S)-4-(Hydroxymethyl)piperidin-3-ol; (3S,4R)-4-(Hydroxymethyl)piperidin-3-ol; 4-Piperidinemethanol, 3-hydroxy-, cis-; 3-Hydroxy-4-hydroxymethylpiperidine; 21492-03-5; cis-4-Hydroxymethyl-3-hydroxypiperidine
EINECS	Contact for details

Quality Control

Our cis-4-(Hydroxymethyl)Piperidin-3-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.