Description

1-Phenyl-4-(Prop-2-Yn-1-Yl)Piperazine is a versatile and high-value piperazine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a phenyl group and a terminal alkyne moiety, makes it an essential intermediate for the development of novel pharmacologically active compounds. This product is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the synthesis of potential drug candidates targeting central nervous system disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Chemical Synthesis Building Block: The terminal alkyne group enables participation in click chemistry reactions, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC), for modular synthesis.
• Ligand Development: Employed in the research and development of selective ligands for various G-protein coupled receptors (GPCRs).
• Agrochemical Research: Investigated as an intermediate for developing new active ingredients with potential pesticidal or herbicidal activity.
• Material Science: Potential use in the synthesis of specialized polymers or functionalized surfaces via its reactive alkyne handle.

Basic Information

Product Name	1-Phenyl-4-(Prop-2-Yn-1-Yl)Piperazine
CAS No.	21057-45-4
Molecular Formula	C13H16N2
Molecular Weight	200.28 g/mol
Synonyms	1-Phenyl-4-(2-propynyl)piperazine; 4-(2-Propyn-1-yl)-1-phenylpiperazine; N-Phenyl-N'-(2-propynyl)piperazine; 1-Phenyl-4-(prop-2-ynyl)piperazine; 1-Phenyl-4-(2-propynyl)piperazine; 21057-45-4; 4-Propargyl-1-phenylpiperazine
EINECS	Contact for details

Quality Control

Our 1-Phenyl-4-(Prop-2-Yn-1-Yl)Piperazine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, open flames, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.