Description

D-Penicillamine Disulfide is a stable, oxidized dimer of the pharmaceutical agent D-penicillamine, widely recognized for its role as a key intermediate and reference standard in biochemical research and pharmaceutical development. This compound is essential for studying thiol-disulfide exchange mechanisms and for the synthesis of more complex molecules. It is primarily utilized by research institutions, pharmaceutical manufacturers, and analytical laboratories focused on rheumatology, metal chelation therapies, and process chemistry.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs) and more complex penicillamine derivatives.
• Biochemical Research: Used as a stable disulfide form in studies of redox biology, enzyme inhibition, and thiol-disulfide interchange reactions.
• Reference Standard: Serves as a high-purity analytical standard for quality control (QC) and assay development in pharmaceutical manufacturing.
• Chelation Chemistry Studies: Employed in research investigating metal ion binding and detoxification pathways.
• Process Development: Utilized in scaling up production processes for drugs related to Wilson's disease, rheumatoid arthritis, and cystinuria.

Basic Information

Product Name	D-Penicillamine Disulfide
CAS No.	20902-45-8
Molecular Formula	C10H20N2O4S2
Molecular Weight	296.41 g/mol
Synonyms	(R,R)-3,3'-Dithiobis(2-amino-3-methylbutanoic acid); D-3,3'-Dithiobis(2-amino-3-methylbutyric acid); (R,R)-Penicillamine Disulfide; D-Pen Disulfide; D(-)-Penicillamine Disulfide; Bis(D-penicillamine); D-PenSSPen-D
EINECS	244-110-8

Quality Control

Our D-Penicillamine Disulfide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and specific tests for related substances. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere); prolonged exposure to air or light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	[α]20/D: Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.