Description

12-o-Acetylphorbol-13-Decanoate is a semi-synthetic derivative of phorbol, a complex diterpene ester. This compound is of significant interest in biochemical and pharmacological research due to its potent biological activity as a protein kinase C (PKC) activator. It is primarily utilized by research institutions and pharmaceutical development companies for studying signal transduction pathways, cellular proliferation, and tumor promotion mechanisms.

Application

• Biochemical Research: As a potent and specific activator of Protein Kinase C (PKC) isoforms for studying intracellular signaling cascades.
• Pharmacological Studies: Used in vitro and in vivo models to investigate the role of PKC in cancer, inflammation, and other disease states.
• Cell Biology: A tool compound for inducing cellular differentiation, apoptosis, or proliferation in various cell lines.
• Drug Discovery: Serves as a reference standard and a molecular probe for screening and developing novel PKC modulators.
• Toxicology Research: Employed in studies of tumor promotion and the mechanisms of action of phorbol esters.
• Academic Research: Fundamental research tool in universities and institutes for dissecting complex biological processes.

Basic Information

Product Name	12-o-Acetylphorbol-13-Decanoate
CAS No.	20839-15-0
Molecular Formula	C32H48O8
Molecular Weight	560.72 g/mol
Synonyms	12-O-Acetylphorbol 13-decanoate; APD; 12-O-Acetyl-4-deoxyphorbol 13-decanoate; Phorbol 12-acetate 13-decanoate; 4-Deoxy-12-O-acetylphorbol 13-decanoate; 12-Acetoxyphorbol 13-decanoate; 12-O-Acetyl-4-deoxy-9-hydroxy-13-oxophorbol 13-decanoate; TPA 13-decanoate
EINECS	Contact for details

Quality Control

Our 12-o-Acetylphorbol-13-Decanoate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including identity confirmation and purity assessment via advanced chromatographic and spectroscopic methods. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to guarantee traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.