Description

Parthenolide CAS NO 20554-84-1 is a high-purity sesquiterpene lactone, a key bioactive compound primarily extracted from *Tanacetum parthenium* (feverfew). This compound is valued for its potent and specific biological activity, making it a critical reference standard and research material. It is essential for pharmaceutical R&D, nutraceutical formulation, and advanced biochemical studies targeting inflammatory pathways.

Application

• Pharmaceutical Research & Development: Serves as a crucial reference standard and active pharmaceutical ingredient (API) intermediate in the development of anti-inflammatory and anti-migraine therapeutics.
• Biochemical & Cell Biology Studies: Used as a selective inhibitor of NF-κB activation, making it a vital tool compound for investigating signaling pathways related to inflammation, cancer, and cell proliferation.
• Nutraceutical Standardization: Employed as a certified reference material to standardize and quantify the active ingredient content in feverfew extract-based dietary supplements.
• Academic Research: A key reagent in university and institutional labs for pharmacological and mechanistic studies of natural products.
• Quality Control Laboratories: Used as an analytical standard in HPLC and LC-MS methods for the purity assessment of botanical extracts and finished products.

Basic Information

Product Name	Parthenolide
CAS No.	20554-84-1
Molecular Formula	C15H20O3
Molecular Weight	248.32 g/mol
Synonyms	(-)-Parthenolide; NSC 628435; Santamarin derivative; 4,5-Epoxy-6β-hydroxygermacra-1(10),11(13)-dien-12-oic acid γ-lactone; Feverfew lactone; 1(10),4(5)-Diepoxy-11(13)-germacradien-12,6-olide
EINECS	243-902-8

Quality Control

Our Parthenolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Melting Point	115°C - 120°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.