Description

2(1H)-Naphthalenone, Octahydro-4,4A-Dimethyl-6-(1-Methylethenyl)-, (4R,4As,6R,8As)- is a high-purity, stereochemically defined decalin derivative with a complex, functionalized structure. This compound matters as a versatile and valuable chiral intermediate for the synthesis of complex natural products and fine chemicals, offering a rigid molecular scaffold for advanced research and development. It is primarily needed by pharmaceutical R&D teams, agrochemical innovators, and specialty chemical manufacturers for applications in asymmetric synthesis and fragrance chemistry. CAS No. 20489-53-6.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of complex drug candidates, particularly in steroid-like or terpenoid-based therapeutic molecules.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its rigid decalin core for bioactive molecule design.
• Fragrance and Flavor Chemistry: Acts as a precursor for high-value aroma chemicals and fixatives due to its complex, woody, and amber-like structural characteristics.
• Organic Synthesis Research: Provides a valuable substrate for methodological studies in catalysis, including hydrogenation, oxidation, and C-H functionalization reactions.
• Material Science: Investigated as a monomer or additive for creating specialized polymers with unique thermal or optical properties.
• Natural Product Synthesis: An essential intermediate for the laboratory synthesis of complex terpenoids and other natural products for biological evaluation.

Basic Information

Product Name	2(1H)-Naphthalenone, Octahydro-4,4A-Dimethyl-6-(1-Methylethenyl)-, (4R,4As,6R,8As)-
CAS No.	20489-53-6
Molecular Formula	C15H24O
Molecular Weight	220.35 g/mol
Synonyms	(4R,4aS,6R,8aS)-4,4a-Dimethyl-6-(prop-1-en-2-yl)decahydronaphthalen-2(1H)-one; (-)-Ambrox; (4R,4aS,6R,8aS)-6-(1-Methylethenyl)decahydro-4,4a-dimethyl-2(1H)-naphthalenone; (6R,8aS)-4,4a-Dimethyl-6-(prop-1-en-2-yl)-4,4a,5,6,7,8,8a,9-octahydro-2H-naphthalen-1-one; Ambroxide; Ambroxan; Amberwood; Amberketone
EINECS	Contact for details

Quality Control

Our 2(1H)-Naphthalenone, Octahydro-4,4A-Dimethyl-6-(1-Methylethenyl)-, (4R,4As,6R,8As)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure high chemical and isomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized and light-sensitive; prolonged exposure to air, heat, or light should be avoided to maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	75 - 80 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.