Description

1-Fluoro-4-Methylbicyclo[2.2.2]octane is a highly functionalized, rigid bicyclic organic compound featuring a fluorine atom at the bridgehead position. This unique structure makes it a valuable and versatile fluorinated building block for advanced chemical synthesis, particularly in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on novel active ingredients, specialty materials, and complex molecular architectures where its steric and electronic properties are critical.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of novel drug candidates, especially for central nervous system (CNS) targets and bioactive molecules requiring a rigid, fluorinated core.
• Agrochemical Research: Used in the synthesis of advanced pesticides and herbicides, where the introduction of fluorine can enhance metabolic stability, bioavailability, and binding affinity.
• Material Science: Acts as a precursor for specialty polymers, liquid crystals, or advanced organic frameworks (MOFs/COFs) where the bicyclo[2.2.2]octane scaffold provides thermal and structural stability.
• Fluorine Chemistry & Catalysis: Employed as a model substrate or ligand precursor in studies of C-F bond activation, fluorination reactions, and the development of new catalytic systems.
• Chemical Probe Development: Utilized in medicinal chemistry to create probes for studying enzyme mechanisms or receptor interactions due to its distinct steric and electronic profile.
• Academic & Industrial R&D: A critical reagent for synthetic organic chemists exploring new reaction methodologies and the construction of complex, three-dimensional molecular libraries.

Basic Information

Product Name	1-Fluoro-4-Methylbicyclo[2.2.2]octane
CAS No.	20417-60-1
Molecular Formula	C9H15F
Molecular Weight	142.21 g/mol
Synonyms	4-Methyl-1-fluorobicyclo[2.2.2]octane; 1-Fluoro-4-methylbicyclo[2.2.2]octane; Bicyclo[2.2.2]octane, 1-fluoro-4-methyl-; 1-Fluoro-4-methyl-2.2.2-octane; 4-Methylbicyclo[2.2.2]octan-1-fluoride
EINECS	Contact for details

Quality Control

Our 1-Fluoro-4-Methylbicyclo[2.2.2]octane is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including GC, NMR, and HPLC, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical specifications. Our quality commitment supports applications in regulated research environments where material integrity is paramount.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is sensitive to strong bases and fluorides; ensure segregation from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	≤ 2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.