Description

2,2-Dimethylpropyl Chloroformate is a specialized alkyl chloroformate ester, a key reagent in organic synthesis and pharmaceutical manufacturing. Its primary value lies in its role as a versatile protecting and activating agent, particularly for introducing the pivaloyloxymethyl (POM) protecting group for sensitive functionalities like carboxylic acids and phosphates. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity intermediates for complex molecule synthesis.

Application

• Pharmaceutical Intermediate Synthesis: Crucial for the production of prodrugs via the introduction of the pivaloyloxymethyl (POM) group to enhance drug bioavailability and stability.
• Peptide Chemistry: Used as a coupling agent or for the temporary protection of amino acids during solid-phase and solution-phase peptide synthesis.
• Agrochemical Manufacturing: Serves as a building block in the synthesis of advanced herbicides, fungicides, and plant growth regulators.
• Polymer Modification: Acts as a functionalization agent to introduce specific end-groups or cross-linking sites into polymer chains.
• Fine Chemical Production: Employed in the multistep synthesis of complex organic molecules, including dyes, flavors, and fragrances.
• Bioconjugation: Facilitates the covalent attachment of small molecules, labels, or polymers to biomolecules like proteins or oligonucleotides.

Basic Information

Product Name	2,2-Dimethylpropyl Chloroformate
CAS No.	20412-38-8
Molecular Formula	C6H11ClO2
Molecular Weight	150.60 g/mol
Synonyms	Neopentyl Chloroformate; Pivaloyloxymethyl Chloride; Chloroformic Acid 2,2-Dimethylpropyl Ester; 1-Chloro-2-methyl-2-propanol Carbonate; POM-Cl; (2,2-Dimethylpropoxy)carbonyl Chloride; Neopentyloxycarbonyl Chloride
EINECS	243-818-7

Quality Control

Our 2,2-Dimethylpropyl Chloroformate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed and handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Acidity (Titration)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.