Description

(R)-2-Hydroxy-4-Methylpentanoic Acid is a high-purity chiral building block and intermediate of significant value in asymmetric synthesis. Its stereochemical purity makes it a critical component for producing enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for research and manufacturing in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular configuration dictates product efficacy.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in cardiovascular and metabolic disease treatments.
• Asymmetric Catalyst Ligand Precursor: Used in the development and production of chiral ligands for metal-catalyzed reactions.
• Fine Chemical Synthesis: Building block for creating complex, high-value molecules in agrochemicals and performance materials.
• Flavor and Fragrance Industry: Intermediate in the production of specific, optically active flavor compounds.
• Biochemical Research: Substrate or standard in enzymatic studies and metabolic pathway analysis.
• Polymer Modification: Monomer for introducing chiral centers into specialty polymers.

Basic Information

Product Name	(R)-2-Hydroxy-4-Methylpentanoic Acid
CAS No.	20312-37-2
Molecular Formula	C6H12O3
Molecular Weight	132.16 g/mol
Synonyms	(R)-2-Hydroxy-4-methylvaleric Acid; D-2-Hydroxy-4-methylpentanoic Acid; (R)-2-Hydroxyisocaproic Acid; (2R)-2-Hydroxy-4-methylpentanoic Acid; (R)-Leucic Acid; (R)-HICA; (R)-2-Hydroxy-4-methylvalerate; (R)-4-Methyl-2-hydroxypentanoic Acid
EINECS	Contact for details

Quality Control

We supply (R)-2-Hydroxy-4-Methylpentanoic Acid in high-purity grades suitable for demanding applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing chiral purity, chemical purity, and impurity profiles are available upon request. We adhere to cGMP principles for production relevant to pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.