Description

N,n-Bis(2-Chloroethyl)Carbamoyl Chloride is a highly reactive bifunctional alkylating agent and a key chemical intermediate. Its value lies in its ability to introduce the chloroethylamine moiety, a crucial pharmacophore in several therapeutic classes, into target molecules. This compound is primarily needed by pharmaceutical R&D and fine chemical synthesis laboratories for the development and production of active pharmaceutical ingredients (APIs), particularly in oncology and other specialized fields.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of nitrogen mustard-based chemotherapeutic agents and other targeted therapies.
• Anticancer Drug Synthesis: Used in the research and production of alkylating antineoplastic drugs, which work by damaging the DNA of cancer cells.
• Bioconjugation & Linker Chemistry: Serves as a versatile linker for attaching cytotoxic payloads to antibodies, proteins, or other targeting molecules in antibody-drug conjugate (ADC) development.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the synthesis of specialized polymers with unique properties.
• Organic Synthesis Reagent: Employed in research laboratories for introducing the 2-chloroethylamine group into complex organic molecules during multi-step synthesis.
• Biochemical Research: Utilized in biochemical studies to modify amino acids, peptides, or nucleotides to study structure-activity relationships.

Basic Information

Product Name	N,n-Bis(2-Chloroethyl)Carbamoyl Chloride
CAS No.	2998-56-3
Molecular Formula	C5H8Cl3NO
Molecular Weight	204.48 g/mol
Synonyms	Carbamic chloride, N,N-bis(2-chloroethyl)-; 1,1'-[Carbonyldi(oxy)]bis[2-chloroethane] (deprecated); N,N-Bis(2-chloroethyl)carbamoyl chloride; Bis(2-chloroethyl)carbamoyl chloride; 2-Chloro-N-(2-chloroethyl)-N-(chloroformyl)ethanamine; Nitrogen mustard carbamoyl chloride; NSC 62262
EINECS	221-081-5

Quality Control

Our N,n-Bis(2-Chloroethyl)Carbamoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.