Description

Ethylchlorothioformate is a versatile and highly reactive organosulfur compound used as a key reagent in organic synthesis. Its primary value lies in its ability to act as a thiocarbonyl transfer agent and a precursor for introducing the thiocarbonylthio (-SC(O)R) functional group into target molecules. This makes it an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and polymer industries, where it is utilized in the synthesis of active ingredients, ligands, and functional materials.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of thioesters, thiocarbamates, and other sulfur-containing bioactive molecules, including potential drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that require a thiocarbonyl moiety for their biological activity.
• Polymer Chemistry: Serves as a chain transfer agent (CTA) or functionalization agent in reversible addition-fragmentation chain-transfer (RAFT) polymerization to create polymers with controlled architectures.
• Organic Synthesis Reagent: Employed in various organic transformations, including the preparation of heterocycles, as a thiocarbonylating agent, and in peptide modification chemistry.
• Chemical Research & Development: A valuable tool for academic and industrial R&D labs exploring new synthetic methodologies and novel sulfur chemistry.
• Material Science: Used to modify surface properties or create functional coatings by introducing thiocarbonyl groups onto materials.

Basic Information

Product Name	Ethylchlorothioformate
CAS No.	2812-73-9
Molecular Formula	C3H5ClOS
Molecular Weight	124.59 g/mol
Synonyms	Chloroethyl thioformate; Ethyl chlorothioformate; Carbonochloridothioic acid O-ethyl ester; Ethyl chloromethanethioate; Thiocarbonyl chloride O-ethyl ester; Ethyl thiochloroformate; O-Ethyl chlorothioformate; Ethyl chlorosulfenylformate
EINECS	220-562-9

Quality Control

Our Ethylchlorothioformate is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (IR, NMR), to verify identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, oxidizing agents, and moisture. Due to its hygroscopic and light-sensitive nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.20 - 1.25 g/mL
Refractive Index (n20D)	1.480 - 1.490

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.