Description

Piperazine-2-Carboxylic Acid is a high-purity, non-proteinogenic amino acid derivative featuring a piperazine ring structure. This compound serves as a critical chiral building block and intermediate in the synthesis of complex pharmaceutical molecules and fine chemicals. It is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors, neurological drugs, and other therapeutic agents.
• Peptide Mimetics & Drug Design: Used to introduce constrained conformational elements into peptide backbones, enhancing stability and biological activity.
• Ligand & Catalyst Synthesis: Employed in the preparation of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Acts as a building block for novel herbicides, fungicides, and plant growth regulators.
• Biochemical Research: Utilized as a standard or reagent in enzymatic studies and metabolic pathway analysis.
• Fine Chemical Synthesis: Serves as a precursor for dyes, complexing agents, and other high-value specialty chemicals.

Basic Information

Product Name	Piperazine-2-Carboxylic Acid
CAS No.	2762-32-5
Molecular Formula	C5H10N2O2
Molecular Weight	130.15 g/mol
Synonyms	D-Pipecolic Acid; (R)-Piperazine-2-carboxylic acid; (R)-Pipecolic Acid; D-Pipecolinic Acid; (R)-(-)-Pipecolic Acid; (R)-2-Piperazinecarboxylic Acid; Hexahydropyridine-2-carboxylic Acid; L-Homoproline (Note: Often refers to the L-enantiomer of pipecolic acid).
EINECS	220-409-6

Quality Control

Our Piperazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.