Description

Benzoyl Chloride, 5-Fluoro-2-Hydroxy- (9Ci) is a specialized fluorinated benzoyl chloride derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its dual reactive sites, enabling the introduction of both a benzoyl group and a protected hydroxyl moiety into target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used to construct advanced fluorinated herbicides, fungicides, and plant growth regulators, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Liquid Crystal & OLED Material Production: Serves as a starting material for creating fluorinated aromatic cores essential in electronic display technologies.
• Polymer Modification: Employed to introduce functional aromatic esters into polymer chains, altering material properties like thermal stability and solubility.
• Complex Ligand & Catalyst Development: Utilized in academic and industrial research to develop novel fluorinated ligands for catalytic processes.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and CDMO (Contract Development and Manufacturing Organization) facilities producing bespoke compounds for clients.

Basic Information

Product Name	Benzoyl Chloride, 5-Fluoro-2-Hydroxy- (9Ci)
CAS No.	2728-74-7
Molecular Formula	C7H4ClFO2
Molecular Weight	174.56 g/mol
Synonyms	5-Fluoro-2-hydroxybenzoyl chloride; 2-Hydroxy-5-fluorobenzoyl chloride; 5-Fluorosalicyloyl chloride; 5-Fluoro-2-hydroxybenzoic acid chloride; 2-Hydroxy-5-fluorobenzoic acid chloride; 5-Fluorosalicylic acid chloride; 5-Fluoro-2-hydroxybenzoyl chloride (9CI)
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-2-hydroxybenzoyl chloride is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic processes. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced analytical techniques such as HPLC, GC, NMR, and IR spectroscopy. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.