Description

11βh,13-Dihydroparthenolide is a high-purity sesquiterpene lactone derivative, recognized for its significant bioactivity and role as a key intermediate in advanced pharmaceutical synthesis. This compound is valued for its potential in research and development of novel therapeutic agents, particularly in anti-inflammatory and anti-cancer applications. It is essential for pharmaceutical R&D laboratories, biotechnology firms, and academic institutions focused on medicinal chemistry and natural product research.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a reference standard and a core scaffold for structure-activity relationship (SAR) studies in drug discovery.
• Natural Product Derivative Synthesis: Serves as a starting material for the semi-synthesis of novel parthenolide analogs with enhanced properties.
• Biochemical Research: Employed in in-vitro studies to investigate mechanisms of action related to NF-κB pathway inhibition and other cellular processes.
• Reference Standard: Utilized in analytical laboratories for method development, validation, and quality control of related substances.

Basic Information

Product Name	11βh,13-Dihydroparthenolide
CAS No.	2513-76-0
Molecular Formula	C15H20O3
Molecular Weight	248.32 g/mol
Synonyms	11βH,13-Dihydroparthenolide; 11β,13-Dihydro-parthenolide; Parthenolide, 11β,13-dihydro-; 4,5-Epoxy-6β-hydroxygermacra-1(10),11(13)-dien-12-oic acid γ-lactone, 11β,13-dihydro-; (3aR,4S,6aR,9aS,9bR)-6a-Hydroxy-3a,4,5,8,9,9a,9b,10-octahydro-4,9b-dimethyl-3H-azuleno[6,5-b]furan-2,7-dione
EINECS	Contact for details

Quality Control

Our 11βh,13-Dihydroparthenolide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, typically determined by HPLC, NMR, and MS. We adhere to cGMP principles for pharmaceutical intermediates, ensuring traceability and documentation for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.