Description

3Alpha,7Alpha-Dihydroxy-12-Oxo-5Beta-Cholan-24-Oic Acid is a high-purity bile acid derivative and a key intermediate in the synthesis of ursodeoxycholic acid (UDCA) and other therapeutic compounds. Its precise stereochemistry and functional groups make it a critical building block for pharmaceutical research and manufacturing, ensuring the efficacy and safety of final drug products. This compound is essential for pharmaceutical companies, research institutions, and fine chemical suppliers engaged in developing hepatoprotective agents, cholesterol regulators, and advanced drug delivery systems.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of Ursodeoxycholic Acid (UDCA), a primary drug for treating gallstones and primary biliary cholangitis.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key chiral synthon for research and development of novel hepatoprotective and choleretic agents.
• Biochemical Research: Used as a reference standard and probe in studies of bile acid metabolism, liver function, and nuclear receptor (e.g., FXR) signaling pathways.
• Fine Chemical Synthesis: Employed in the production of other modified bile acids and steroid derivatives with potential therapeutic applications.
• Quality Control & Analytical Standards: Provides a high-purity standard for HPLC, LC-MS, and other analytical methods to ensure quality in pharmaceutical manufacturing.

Basic Information

Product Name	3Alpha,7Alpha-Dihydroxy-12-Oxo-5Beta-Cholan-24-Oic Acid
CAS No.	2458-08-4
Molecular Formula	C24H38O5
Molecular Weight	406.56 g/mol
Synonyms	12-Ketochenodeoxycholic Acid; 3α,7α-Dihydroxy-12-oxo-5β-cholan-24-oic Acid; 12-Oxochenodeoxycholic Acid; 12-Keto-CDCA; 12-Oxo-CDCA; NSC 72178; 12-Ketolithocholic Acid (ambiguous, verify context)
EINECS	219-522-7

Quality Control

Our 3Alpha,7Alpha-Dihydroxy-12-Oxo-5Beta-Cholan-24-Oic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by IR and NMR, to ensure it meets stringent specifications for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed-upon specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.