Description

5-Methoxy-α-Oxo-1H-Indole-3-Acetyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. This compound matters because it serves as a critical building block for constructing complex heterocyclic molecules, enabling the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for process development and scale-up.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of indole-based drug candidates, including potential anti-inflammatory and neurological agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and plant growth regulators.
• Fine Chemical Production: Serves as a versatile building block for creating complex dyes, pigments, and advanced organic materials.
• Academic & Contract Research: A valuable reagent for medicinal chemistry programs and structure-activity relationship (SAR) studies in university and CRO laboratories.
• Peptide Mimetic Development: Employed in the design and synthesis of peptidomimetics and other bioactive molecules.

Basic Information

Product Name	5-Methoxy-α-Oxo-1H-Indole-3-Acetyl Chloride
CAS No.	2426-19-9
Molecular Formula	C12H10ClNO3
Molecular Weight	251.67 g/mol
Synonyms	5-Methoxy-1H-indole-3-glyoxyloyl chloride; 5-Methoxy-3-indoleglyoxylic acid chloride; 5-Methoxy-α-oxo-1H-indole-3-acetic acid chloride; 5-Methoxyindole-3-glyoxyloyl chloride; 3-(Chlorooxoacetyl)-5-methoxy-1H-indole; 5-Methoxy-3-indolylglyoxyloyl chloride; 5-Methoxyoxindole-3-carbonyl chloride (common misnomer); 2426-19-9
EINECS	Contact for details

Quality Control

Our 5-Methoxy-α-Oxo-1H-Indole-3-Acetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting standards for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in common organic solvents (DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.